Journal: Pharmaceutics

Article Title: Synergistic Activity and Mechanism of Sanguinarine with Polymyxin B against Gram-Negative Bacterial Infections

doi: 10.3390/pharmaceutics16010070

Figure Lengend Snippet: MICs and FICIs of PMB with SA against Gram-negative bacterial strains.

Article Snippet: A total of 7 bacterial strains employed in this study were purchased from BeNa Culture Collection (Beijing, China), including 3 Escherichia coli standard strains (ATCC 25922, 11775, 9637, Manassas, VA, USA), a resistant Escherichia coli strain (ATCC 35218, an E. coli strain producing extended-spectrum β -lactamases and resistant to β -lactam antibiotics), a Klebsiella pneumoniae strain (ATCC 700603, a K. pneumoniae strain producing extended-spectrum β -lactamases and resistant to β -lactam antibiotics), a Pseudomonas aeruginosa strain (ATCC 27853), and an Acinetobacter baumannii strain (ATCC 19606).

Techniques:

Journal: MedChemComm

Article Title: Design, synthesis and antibacterial evaluation of a polycationic calix[4]arene derivative alone and in combination with antibiotics † †Electronic supplementary information (ESI) available: NMR and HR ESI-MS spectra of calix[4]arene derivative 2 . See DOI: 10.1039/c7md00527j

doi: 10.1039/c7md00527j

Figure Lengend Snippet: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of calix[4]arene derivative 2 and antibiotics (μg mL –1 ), MIC (μg mL –1 ) and fractional inhibitory concentration index (FICI) of calix[4]arene 2 /antibiotic combinations

Article Snippet: The in vitro activity of compound 2 , alone and in combination with known antibiotics (ofloxacin, chloramphenicol or tetracycline), was assessed against strains of Staphylococcus aureus (ATCC 6538 and methicillin-resistant isolate 15), S. epidermidis (ATCC 35984 and methicillin-resistant isolate 57), and Pseudomonas aeruginosa (ATCC 9027 and antibiotic-resistant isolate 1).

Techniques: Concentration Assay